Sperm increased hds
A low number of patients received IUI with low success rate, and statistical analysis was therefore not performed. Couples diagnosed with male infertility had a significantly higher level of DFI compared to couples with idiopathic fertility. Sperm head morphology showed low but significant correlations with the SCSA variables. During the last steps of spermatogenesis, the sperm nucleus condenses, and the characteristic shape of the sperm head is formed. The result is a highly packaged chromatin structure, with apparently no DNA transcription or RNA translation taking place. The capacity of the maturing sperm cells for DNA repair is greatly reduced, and their ability to respond to damage by undergoing programmed cell death is progressively lost Aitken et al.
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SCSA Diagnostics: DFI Research
Try out PMC Labs and tell us what you think. Learn More. Language: English French. However, data on what exactly this parameter reveals, its relevance and usefulness are contradictory. The objective of this study was thus to answer the question of whether HDS is a relevant and reliable parameter to be taken into account?
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Could high DNA stainability (HDS) be a valuable indicator of sperm nuclear integrity?
Such patients are counseled to try ICSI fertilization. Menezo, one of the leading infertility specialists in France, states, "a strict check of sperm is mandatory before all assisted reproduction treatment. Moderate to high DNA fragmentation levels found within these red fluorescing sperm are likely beyond the DNA repair capacity of the egg.
Bungum, P. Humaidan, M. Spano, K.
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